SALT LAKE CITY (AP) — Vice President Mike Pence and his Democratic challenger, California Sen. Kamala Harris, are poised to meet for a debate that will offer starkly different visions for a country confronting escalating crises.

The faceoff Wednesday night in Salt Lake City is the most highly anticipated vice presidential debate in recent memory. It will unfold while President Donald Trump recovers at the White House after testing positive last week for the coronavirus and spending several days in the hospital.

Ultimately, the debate is a chance for voters to decide whether Pence and Harris are in a position to step into the presidency at a moment’s notice. It’s hardly a theoretical question as the 74-year-old Trump combats the virus, and Biden, at 77, would become the oldest person to become president if he’s elected.

While the debate will likely cover a range of topics, the virus will be at the forefront.

Pence and Harris will appear on stage exactly 12.25 feet apart separated by plexiglass barriers. Anyone in the small audience who refuses to wear a mask will be asked to leave.